We just returned from a quick 48-hour trip to New Mexico. The Santa Fe area is perfect for a weekend getaway from Denver, and February is off-season so there are great deals on hotels.
Santa Fe is a 6 hour drive from Denver, straight down I-25 - or a bit longer if you take the scenic route, via highway 285, which passes between the San Juan and Sangre de Cristo mountain ranges all the way across the Colorado/New Mexico border.
Highlights of the trip include:
Lunch at The Shed - a Santa Fe institution, located just off of the plaza in a hacienda dating back to 1692
Spa treatments and a delicious dinner at Ten Thousand Waves - a Japanese spa set on a hillside on the way to the ski area
Breakfast at Cafe Pasqual's, another local institution with organic and local food
Browsing the charming shops and galleries in the historic plaza and along Canyon Road